Does AMP-activated protein kinase negatively mediate aged fast-twitch skeletal muscle mass?

نویسندگان

  • Scott E Gordon
  • Jordan A Lake
  • Christopher M Westerkamp
  • David M Thomson
چکیده

The activity of 5'-adenosine monophosphate (AMP)-activated protein kinase (AMPK), a negative regulator of cell size, is up-regulated with age in resting and overloaded fast-twitch skeletal muscle but not slow-twitch muscle. Here, we provide evidence to support the hypothesis that elevated AMPK activity plays a potentially important integrative role in the age-related atrophy and diminished capacity for growth specific to fast-twitch skeletal muscle.

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عنوان ژورنال:
  • Exercise and sport sciences reviews

دوره 36 4  شماره 

صفحات  -

تاریخ انتشار 2008